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3-hydroxymethyl butyrate


NMB is a derivative of the essential amino acid Leucine. The use of NMS in sports.

NMB (3-hydroxymethyl butyrate)

NMB (3-hydroxymethyl butyrate) is a metabolite that occurs after the breakdown of leucine. This is an amino acid that our body produces in small quantities. Approximately five percent of the leucine that comes with food is converted to the UHF. In fact, this means that the human body, leading a sedentary lifestyle, produces from 0.2 to 0.4 grams of UHF per day.

Although leucine seems to play the role of the most powerful regulator of muscle growth, some scientists believe that its activity is indirect. Apparently, the effect of leucine becomes most effective only after it turns into a metabolite. It has been hypothesized that the NIV can reproduce the vast majority of the properties of leucine.

3-hydroxymethyl butyrate

Initially, NMV was used with some success to build muscle in animals (M. Van Koevering, 1994). On an animals muscle placed in a test tube, the NMB appears to have an effect that prevents catabolism, especially if it is used simultaneously with omega-3 (G. Smith, 2004).

The results of the very first study of the use of HMW in humans were published in 1996 by S. Nissen. According to this publication, novice athletes received either three grams of UHF daily for three weeks or a placebo for seven weeks.

After three weeks of taking HMB, muscle catabolism decreased by 20-60 percent compared with placebo..

After seven weeks of taking UHF, muscles increased by 2.3 kilograms versus 800 grams when taking a placebo. Strength increased by 13 and eight percent, respectively. Nevertheless, if we take into account the permissible errors, the results obtained do not make much impression..

athletes involved

! On a note. No matter how 3-hydroxymethylbutyrate resembles leucine, its benefits remain controversial..

Although some other studies support Nissens results, J. Hoffman (2004) did not reveal the slightest positive effect of the NLM on catabolism or strength in athletes involved in American football.

Another study, also with the participation of athletes involved in American football, did not record a more significant increase in muscle mass and strength when taking UHF for one month than when taking a placebo (J. Ransone, 2003). Approximately the same results were obtained by G. Slater (2001), who used the NMW for six weeks..

If we talk about the safety of NMB, then in rats that were given very high doses of this drug for 91 days, no side effects were observed (Baxter, 2005). Trained athletes who took three grams of UHF daily for six weeks did not experience any disturbances that can be noticed or measured (M. Crowe, 2003).

Probably, the NWM could find application in sports disciplines requiring endurance (M. Vukovich, 2001). This amino acid appears to be able to promote the use of fatty acids as an energy source, thus saving muscle glycogen stores.

amino acid, 3-hydroxymethyl butyrate, American football, athletes involved